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Home Antibody All anti-CYCS antibodies

Anti-CYCS Antibody EP1326Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301005
  • Rabbit Monoclonal Antibody against CYCS (Clone EP1326Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC402715) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(2)
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Also for CYCS (NM_018947)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human Cytochrome C was used as an immunogen.
Clone NameEP1326Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:250; IHC: 1: 100; ICC: 1:50; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens cytochrome c, somatic (CYCS)
Alternative NameCYC; HCS; THC4
Database LinkNP_061820
FunctionCytochrome c is located in the mitochondria of all aerobic cells and is involved in the electron transport system that functions in oxidative phosphorylation. It accepts electrons from cytochrome b and transfers them to cytochrome oxidase. In the process, the iron of the heme group, which is identical to that of hemoglobin and myoglobin, shifts from the ferrous to the ferric state (1). Recent progress in studies on apoptosis has revealed that cytochrome c is a pro-apoptotic factor. It is released from its places on the outer surface of the inner mitochondrial membrane at early steps of apoptosis and, combining with some cytosolic proteins, activates conversion of the latent apoptosis-promoting protease pro-caspase-9 to its active form. Cytochrome c release can be initiated by the pro-apoptotic protein Bax. This process is blocked by the anti-apoptotic proteins Bcl-2 and Bcl-xL (2). Also, differences in amino acid composition of cytochrome c have also been used as markers of biochemical evolution.
Related Pathway
Apoptosis

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WB Image
Western blot - Cytochrome C antibody [EP1326Y]; Anti-Cytochrome C antibody [EP1326Y] at 1/500 dilution + HeLa cell lysate at 10 µg.Secondary.goat anti-rabbit HRP at 1/1000 dilution.Observed band size : 14 kDa .
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytochrome C antibody [EP1326Y]; TA301005, at a 1/100 dilution, staining human Cytochrome C in heart muscle by Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Cytochrome C antibody [EP1326Y]; TA301005, at a 1/100 dilution, staining human Cytochrome C in kidney by Immunohistochemistry Formalin/PFA-fixed paraffin-embedded tissue.

 

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