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Home Antibody All anti-PRKCD antibodies

Anti-PRKCD Antibody EP1484Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300949
  • Rabbit Monoclonal Antibody against PRKCD (Clone EP1484Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403724) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for PRKCD (NM_212539)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human PKC delta was used as an immunogen.
Clone NameEP1484Y IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; FC: 1:15; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:50 - 1:100
BufferDoes not react with Mouse, Rat. Is unsuitable for IP.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for IP.

Reference Data

Target NameHomo sapiens protein kinase C, delta (PRKCD), transcript variant 2
Alternative NameCVID9; MAY1; nPKC-delta; PKCD
Database LinkNP_997704
Entrez Gene 5580 Human
FunctionPKC-delta has a biological activity which is closely related to Pkc1, and PKC-delta activates the Pkc1-mediated pathway through an activation of the Bck1 kinase. PKC-delta appears to play a critical role in growth control of yeast and mammalian cells. Suppression experiments suggest that PKC-delta desensitizes the pathway by regulating an aspect of G protein function (1). PKC-delta phosphorylates hRad9 in vitro and in cells exposed to genotoxic agents. It has been shown that PKC-delta is required for binding of hRad9 to Bcl-2. In concert with these results, inhibition of PKC-delta attenuates Rad9-mediated apoptosis. These findings demonstrate that PKC-delta is responsible for the regulation of Rad9 in the Hus1-Rad1 complex and in the apoptotic response to DNA damage (2). It has been reported a mechanism for the regulation of peripheral B-cell survival by serine/threonine protein kinase Cdelta (PKC-delta): spontaneous death of resting B cells is regulated by nuclear localization of PKC-delta that contributes to phosphorylation of histone H2B at serine 14 (S14-H2B) (3).
Related PathwayProtein KinaseDruggable Genome Chemokine signaling pathwayVascular smooth muscle contractionTight junctionFc epsilon RI signaling pathwayFc gamma R-mediated phagocytosisNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - PKC delta antibody [EP1484Y]; Anti-PKC delta antibody [EP1484Y] at 1/500 dilution + Hela cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP labeled at 1/2000 dilution.Predicted band size : 77 kDa.Observed band size : 77 kDa.

 

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