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Home Antibody All anti-KRT5 antibodies

Anti-KRT5 Antibody EP1601Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300887
  • Rabbit Monoclonal Antibody against KRT5 (Clone EP1601Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400149) , 20ug Explanation
100ul 325 In Stock
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WB(1)
IHC(7)
IF(1)

OriGene Data

ImmunogenA synthetic peptide corresponding to residues on the C-terminus of human CK-5 was used as an immunogen.
Clone NameEP1601Y IsotypeTissue culture supernatant
Species ReactivityMouse, Human (Does not react with: Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsIHC-Fr: Use at an assay dependent concentration; ICC/IF: Use at an assay dependent dilution; WB: 1:10000; IHC-P: Use at an assay dependent dilution
BufferDoes not react with Rat. Is unsuitable for Flow Cyt.
Purification PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens keratin 5 (KRT5)
Alternative NameCK5; DDD; DDD1; EBS2; K5; KRT5A
Database LinkNP_000415
Entrez Gene 3852 Human
Entrez Gene 110308 Mouse
FunctionKeratins are a family of structurally related proteins that form the intermediate filament cytoskeleton in epithelial cells. The 58-kD keratin CK-5 is highly similar to other type II keratins and less similar to type I keratins and other intermediate filament proteins. The 58-kD keratin is regulated by retinoids in several tissues and is one of four keratins abundantly expressed in epidermal keratinocytes, where it may be important in maintaining structural integrity of the integument (1). Keratin 5 (CK-5) mRNA and protein are shown to be expressed in normal mammary epithelial cells in culture and are absent from tumor-derived cell lines. This makes CK-5 an important marker in the tumorigenic process, distinguishing normal from tumor cells, and decreased CK-5 expression correlates with tumorigenic progression (2). Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis characterized by progressive and disfiguring reticulate hyperpigmentation of the flexures. Loss of function of CK-5 suggests a crucial role for keratins in the organization of cell adhesion, melanosome uptake, organelle transport, and nuclear anchorage (3).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Cytokeratin 5 antibody [EP1601Y]; Anti-Cytokeratin 5 antibody [EP1601Y] at 1/10000 dilution + A431 cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 62 kDa.Observed band size : 62 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Cytokeratin 5 antibody [EP1601Y]; Human transitional urinary bladder carcinoma stained with TA300887 at 1/100 - 1/250 dilution.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cytokeratin 5 antibody [EP1601Y](TA300887); TA300887 showing positive staining in Basal cell breast carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cytokeratin 5 antibody [EP1601Y](TA300887); TA300887 showing negative staining in Ductal breast carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cytokeratin 5 antibody [EP1601Y](TA300887); TA300887 showing positive staining in Squamous cell cervical carcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cytokeratin 5 antibody [EP1601Y](TA300887); TA300887 showing negative staining in Stomach adenocarcinoma tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cytokeratin 5 antibody [EP1601Y](TA300887); TA300887 showing positive staining in Normal tonsil squamous cells tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)-Anti-Cytokeratin 5 antibody [EP1601Y](TA300887); TA300887 showing positive staining in Squamous cell lung carcinoma tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - Cytokeratin 5 antibody [EP1601Y]; A431 cells stained with TA300887 at 1/100 - 1/250

 

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