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Anti-CASP6 Antibody EP1325Y

* Buy one primary antibody, get 50% off a GAPDH loading control antibody.

WB(1)

IHC(1)

IF(1)

OriGene Data

Immunogen	A synthetic peptide corresponding to residues of human Caspase-6 was used as immunogen. The antibody should recognize the pro-form of Caspase-6.
Clone Name	EP1325Y	Isotype	IgG
Species Reactivity	Human, Mouse, Rat	Concentration
Guaranteed Application *	WB, IHC, IF	Suggested Dilutions	WB: 1:20,000; IHC: 1: 100 250; ICC: 1: 100 250; FC: 1:50; IP: 1:50
Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Purification	(Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha
Alternative Name	MCH2
Database Link	NP_001217
Function	Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4).
Related Pathway	Apoptosis MAPK signaling pathway

Related Lysate from OriGene • Transient overexpression lysate of caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • CASP6 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • CASP6 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Casp6 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • CASP6 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Casp6 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha as transfection-ready DNA • Lenti ORF clone of Human caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha, mGFP tagged • GFP-tagged ORF clone of Homo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha as transfection-ready DNA • Lenti ORF clone of Human caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha , Myc-DDK-tagged • Myc-DDK-tagged ORF clone of Homo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)