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Anti-CASP6 Antibody EP1325Y
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Also for CASP6 (NM_001226)
|A synthetic peptide corresponding to residues of human Caspase-6 was used as immunogen. The antibody should recognize the pro-form of Caspase-6.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1:20,000; IHC: 1: 100 250; ICC: 1: 100 250; FC: 1:50; IP: 1:50
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens caspase 6, apoptosis-related cysteine peptidase (CASP6), transcript variant alpha|
|Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-6 is a major apoptotic executioner (1,2). It exists as a pro-domain protein and is cleaved by caspase-3 into two active subunits, an 18 kDa and a 10 kDa subunit (3). Caspase-6 cleaves among many different intracellular proteins, nuclear lamins. Lamins play a significant role in maintaining the integrity of the cell membrane, and their cleavage results in subsequent cellular breakdown and death (4). |
MAPK signaling pathway
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Western blot analysis on MCF-7 cell lysate using anti-Pro Caspase-6, dilution 1:20,000.
Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-Pro Caspase-6.
Immunofluorescent staining of HeLa cells using anti-Pro-Caspase-6.