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Home Antibody All anti-SOD1 antibodies

Anti-SOD1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300827
  • Rabbit Polyclonal Antibody against SOD1
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400160) , 20ug Explanation
100ul 379 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for SOD1 (NM_000454)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-terminus of human SOD1 was used as an immunogen.
Clone Name IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1: 5000; IHC: 1:50 100; ICC: 1:50 100; IP: 1:20
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Immunogen affinity purified
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens superoxide dismutase 1, soluble (SOD1)
Alternative NameALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD
Database LinkNP_000445
Entrez Gene 6647 Human
FunctionThe eukaryotic copper,zinc superoxide dismutases are remarkably stable dimeric proteins that maintain an intrasubunit disulfide bond in the reducing environment of the cytosol and are active under a variety of stringent denaturing conditions. The structural interplay of conserved disulfide bond and metal-site occupancy in human copper,zinc superoxide dismutase (SOD1) is of increasing interest as these post-translational modifications are known to dramatically alter the catalytic chemistry, the subcellular localization, and the susceptibility of the protein to aggregation (1). Defective SOD is linked to motor neuron death and carries implications for understanding and possible treatment of the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS). A crystal structure of human SOD, along with two other SOD structures, established that all 12 observed FALS mutant sites alter conserved interactions critical to the beta-barrel fold and dimer contact, rather than catalysis (2).
Related Pathway
Hemostasis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Superoxide Dismutase 1 antibody; Anti-Superoxide Dismutase 1 antibody at 1/5000 dilution + Jurkat cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 16 kDa.Observed band size : 16 kDa.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - Superoxide Dismutase 1 antibody; TA300827 at 1/50 dilution staining Superoxide Dismutase 1 in human placenta by Immunohistochemistry, Paraffin embedded tissue.
IF Image
Immunocytochemistry/ Immunofluorescence - Superoxide Dismutase 1 antibody; TA300827 at 1/50 dilution staining Superoxide Dismutase 1 in HeLa cells by Immunofluorescence.

 

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