Home Antibody All anti-SOD1 antibodies
Also for SOD1 (NM_000454)
|A synthetic peptide corresponding to residues near the N-terminus of human SOD1 was used as an immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|WB, IHC, IF
||WB: 1: 5000; IHC: 1:50 100; ICC: 1:50 100; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Immunogen affinity purified
|Does not react with Mouse, Rat
|Homo sapiens superoxide dismutase 1, soluble (SOD1)|
|ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD|
Entrez Gene 6647 Human
|The eukaryotic copper,zinc superoxide dismutases are remarkably stable dimeric proteins that maintain an intrasubunit disulfide bond in the reducing environment of the cytosol and are active under a variety of stringent denaturing conditions. The structural interplay of conserved disulfide bond and metal-site occupancy in human copper,zinc superoxide dismutase (SOD1) is of increasing interest as these post-translational modifications are known to dramatically alter the catalytic chemistry, the subcellular localization, and the susceptibility of the protein to aggregation (1). Defective SOD is linked to motor neuron death and carries implications for understanding and possible treatment of the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS). A crystal structure of human SOD, along with two other SOD structures, established that all 12 observed FALS mutant sites alter conserved interactions critical to the beta-barrel fold and dimer contact, rather than catalysis (2). |
|Druggable Genome Amyotrophic lateral sclerosis (ALS)Huntington's diseasePrion diseases|
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Western blot - Superoxide Dismutase 1 antibody; Anti-Superoxide Dismutase 1 antibody at 1/5000 dilution + Jurkat cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 16 kDa.Observed band size : 16 kDa.
Immunohistochemistry (Paraffin-embedded sections) - Superoxide Dismutase 1 antibody; TA300827 at 1/50 dilution staining Superoxide Dismutase 1 in human placenta by Immunohistochemistry, Paraffin embedded tissue.
Immunocytochemistry/ Immunofluorescence - Superoxide Dismutase 1 antibody; TA300827 at 1/50 dilution staining Superoxide Dismutase 1 in HeLa cells by Immunofluorescence.