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Home Antibody All anti-MMP3 antibodies

Anti-MMP3 Antibody EP1186Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300812
  • Rabbit Monoclonal Antibody against MMP3 (Clone EP1186Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419341) , 20ug
100ul 325 In Stock
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WB(1)
IHC(2)
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Also for MMP3 (NM_002422)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human MMP-3 was used as an immunogen
Clone NameEP1186Y IsotypeIgG
Species ReactivityHuman,Mouse,Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000; IHC-P: Use at an assay dependent dilution; ICC/IF: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for Flow Cyt or IP.

Reference Data

Target NameHomo sapiens matrix metallopeptidase 3 (stromelysin 1, progelatinase) (MMP3)
Alternative NameCHDS6; MMP-3; SL-1; STMY; STMY1; STR1
Database LinkNP_002413
FunctionEffective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, and arthritis (1). Matrix metalloproteinase-3 (MMP-3) is a protein involved in tumor invasion and metastasis. MMP3 (stromelysin) is a secreted metalloprotease with a wide range of substrate specificities. MMP3 is synthesized in a preproenzyme form with a calculated size of 54 kDa and a 17-amino acid long signal peptide. Data indicate that the expression and the possible involvement of secreted metalloproteases in tumorigenesis result from a specific interaction between the transforming factor and the target cell, which may vary in different species (2). In neural studies, matrix metalloproteinase-3 (MMP-3) was newly induced and activated in stressed dopamine cells, and the active form of MMP-3 (actMMP-3) was released into the medium. The released actMMP-3, as well as catalytically active recombinant MMP-3 (cMMP-3) led to microglial activation and superoxide generation in microglia and enhanced DA cell death. (3).
Related Pathway

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WB Image
Western blot - MMP3 antibody [EP1186Y]; Anti-MMP3 antibody [EP1186Y] - Carboxyterminal end at 1/1000 dilution + Recombinant protein (0.5ng).Secondary.Goat anti-Rabbit HRP labeled at 1/2000 dilution.Predicted band size : 54 kDa.Observed band size : 50 kDa .
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - MMP3 antibody [EP1186Y]; Ab52915 (1:100) staining human MMP3 in human gastric carcinoma tissue by immunohistochemistry using paraffin embedded tissue.
IHC Image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP3 antibody [EP1186Y] - Carboxyterminal end; Immunohistochemical analysis of rat spinal tissue, staining MMP3 with TA300812. Sections were incubated with primary antibody in 2% BSA in PBS at a dilution of 1/250 overnight at 4°C. An AlexaFluor?488-conjugated anti-rabbit IgG (1/100) was used as the secondary antibody.

 

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