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Anti-TNF Antibody EP1085Y
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|A synthetic peptide corresponding to the extracellular portion of human TNF-a was used as immunogen.|
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens tumor necrosis factor (TNF)|
|DIF; TNF-alpha; TNFA; TNFSF2|
|Tumor necrosis factor is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. Tumor necrosis factor-alpha (TNF-?), the product of activated monocytes, is secreted by macrophages in response to inflammation, infection and cancer (1). TNF-? triggers a signaling cascade, converging on the activation of the transcription factor NF-kappa B, which forms the basis for numerous physiological and pathological processes (2). TNF-? has been shown to play a role in systems such as the pathogenesis of psoriasis, tuberculosis, obesity, cerebral malaria, rheumatoid arthritis and asthma (3). |
Cytokine-cytokine receptor interaction
Hematopoietic cell lineage
MAPK signaling pathway
TGF Beta Signaling Pathway
Toll-like receptor signaling pathway
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Western blot analysis using anti-TNF-α, dilution 1:500.