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Home Antibody All anti-TNF antibodies

Anti-TNF Antibody EP1085Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300746
  • Rabbit Monoclonal Antibody against TNF (Clone EP1085Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC424626) , 20ug Explanation
100ul 325 3-7 Days
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WB(1)
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Also for TNF (NM_000594)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to the extracellular portion of human TNF-a was used as immunogen.
Clone NameEP1085Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500
Predicted MW Explanation 26 kDa
BufferpH: 7.40
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol, 0.05% BSA
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens tumor necrosis factor (TNF)
Alternative NameDIF; TNF-alpha; TNFA; TNFSF2
Database LinkNP_000585
Entrez Gene 7124 Human
FunctionTumor necrosis factor is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. Tumor necrosis factor-alpha (TNF-?), the product of activated monocytes, is secreted by macrophages in response to inflammation, infection and cancer (1). TNF-? triggers a signaling cascade, converging on the activation of the transcription factor NF-kappa B, which forms the basis for numerous physiological and pathological processes (2). TNF-? has been shown to play a role in systems such as the pathogenesis of psoriasis, tuberculosis, obesity, cerebral malaria, rheumatoid arthritis and asthma (3).
Related PathwaySecreted ProteinTransmembraneTranscription FactorsDruggable Genome MAPK signaling pathwayCytokine-cytokine receptor interactionApoptosisTGF-beta signaling pathwayToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - TNF alpha antibody [EP1085Y]; Anti-TNF alpha antibody [EP1085Y] at 1/500 dilution + recombinant protein at 15 ug.Predicted band size : 26 kDa.Observed band size : 18 kDa .

 

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