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Anti-TNF Antibody EP1085Y
|A synthetic peptide corresponding to the extracellular portion of human TNF-a was used as immunogen.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
|pH: 7.40Preservative: 0.01% Sodium azideConstituents: 50% Glycerol, 0.05% BSA|
|Does not react with Mouse, Rat
|Homo sapiens tumor necrosis factor (TNF)|
|DIF; TNF-alpha; TNFA; TNFSF2|
Entrez Gene 7124 Human
|Tumor necrosis factor is a multifunctional proinflammatory cytokine, with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function. Tumor necrosis factor-alpha (TNF-?), the product of activated monocytes, is secreted by macrophages in response to inflammation, infection and cancer (1). TNF-? triggers a signaling cascade, converging on the activation of the transcription factor NF-kappa B, which forms the basis for numerous physiological and pathological processes (2). TNF-? has been shown to play a role in systems such as the pathogenesis of psoriasis, tuberculosis, obesity, cerebral malaria, rheumatoid arthritis and asthma (3). |
|Secreted ProteinTransmembraneTranscription FactorsDruggable Genome MAPK signaling pathwayCytokine-cytokine receptor interactionApoptosisTGF-beta signaling pathwayToll-like receptor signaling pathwayNOD-like receptor signaling pathwayMore Pathways >> |
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Western blot - TNF alpha antibody [EP1085Y]; Anti-TNF alpha antibody [EP1085Y] at 1/500 dilution + recombinant protein at 15 ug.Predicted band size : 26 kDa.Observed band size : 18 kDa .