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Anti-MUC1 Antibody EP1024Y
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Also for MUC1 (NM_002456)
|A synthetic peptide corresponding to residues near the N-terminus of human MUC1 was used as an immunogen.|
|Human, Mouse, Rat
||WB: 1: 1000; IHC: 1: 100 250; FC: 1:30; IP: 1:50
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens mucin 1, cell surface associated (MUC1), transcript variant 1|
|CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM|
|Mucins are high molecular weight glycoproteins that provide a protective layer on epithelial surfaces and are involved in cell-cell interactions, signaling, and metastasis. MUC1 consists of an extracellular subunit and a membrane-associated subunit (1). The two moieties are produced from a single precursor polypeptide by an early proteolytic cleavage event but remain associated throughout intracellular processing and transport to the cell surface. It has been shown that MUC1 expression inhibits erbB1 (regulators of cell survival and growth) degradation and also E-cadherin (2). Isoform 7 of MUC1 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling (3). |
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Western blot analysis on T47D cell lysate using anti-MUC1, dilution 1:1000.
Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-MUC1.