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Anti-CRK Antibody EP242Y


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA300694 Rabbit Monoclonal Antibody against CRK (Clone EP242Y) 100ul $325 In Stock
LC402580 CRK HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the second SH3 domain and near C-terminus of human Crk (p38) protein was used as immunogen.
Clone NameEP242Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1: 10,000; ICC: 1:250-500; IP: 1:50
Predicted MW Explanation 34 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens v-crk avian sarcoma virus CT10 oncogene homolog (CRK), transcript variant II
Alternative NameCRKII; p38
Database LinkNP_058431
Entrez Gene 1398 Human
Entrez Gene 12928 Mouse
Entrez Gene 54245 Rat
FunctionCrk (p38) are adaptor proteins, composed mostly of SH2 and SH3 domains, which play a key role in cellular signaling by mediating the construction of protein complexes and also by managing cell proliferation, differentiation, and migration (1). They are critical integrators of upstream signals for cell invasion and migration in human cancer cell lines. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers (2). In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth (3). Crk associates with ERM family proteins (including ezrin, radixin, and moesin), activates RhoA, and promotes cell motility toward hyaluronic acid (4).
Related PathwayTranscription FactorsDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwayFocal adhesionFc gamma R-mediated phagocytosisNeurotrophin signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Crk p38 antibody [EP242Y]; Anti-Crk p38 antibody [EP242Y] at 1/10000 dilution + HepG2 cell lysate at 10 ug.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 34 kDa.Observed band size : 37 kDa .

IF Image
Immunocytochemistry/ Immunofluorescence - Crk p38 antibody [EP242Y]; Immunofluorescent staining of HeLa cells using TA300694 at a 1/250 dilution.


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