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Also for RASA1 (NM_002890)
|A synthetic peptide corresponding to residues in the C-terminus of human RasGAP was used as immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:5000; IHC-P: Use at an assay dependent dilution; ICC: 1:100 - 1:250; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Protein A purified
|Is unsuitable for Flow Cyt.
|Homo sapiens RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1|
|CM-AVM; CMAVM; GAP; p120GAP; p120RASGAP; PKWS; RASA; RASGAP|
|RasGAP, a regulator of Ras and Rho, stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. RasGAP is a Caspase 3 substrate (1) and acts as both pro- and anti-apoptotic protein depending on the extent of its cleavage by caspases (2). At low levels of caspase activity, RasGAP is cleaved at position 455, generating an N-terminal fragment (fragment N) and a C-terminal fragment (fragment C). Fragment C alone can induce apoptosis, but this response is completely inhibited by fragment N (3). Fragment N appears to be a general blocker of apoptosis downstream of caspase activation because it inhibits caspase 9-induced cell death. At higher caspase activity, fragment N is further processed and Cleavage of fragment N abrogates its protective functions, and hence the second cleavage of RasGAP promotes apoptosis (4).|
EGFR1 Signaling Pathway
MAPK signaling pathway
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Immunohistochemistry - Anti-RASA1 antibody; TA300635 at a 1:100 dilution staining RASA1 in Human breast carcinoma tissue.