Read Promotion Error: could not connect to redis Instance at 127.0.0.1:6912 Anti-CDKN2A Antibody, EP435Y - OriGene
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Anti-CDKN2A Antibody EP435Y

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SKU Description Amount Price Availability*  
TA300632 Rabbit Monoclonal Antibody against CDKN2A (Clone EP435Y) 100ul In Stock
LC400022 CDKN2A HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
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Also for CDKN2A (NM_000077)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenThe human recombinant protein p16/INK4a was used as immunogen.
Clone NameEP435Y IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:500 - 1:2000; FC: 1:10; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant
Note Is unsuitable for ICC or IHC.

Reference Data

Target NameHomo sapiens cyclin-dependent kinase inhibitor 2A (CDKN2A), transcript variant 1
Alternative NameARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4;
Database LinkNP_000068
Entrez Gene 1029 Human
Functionp16 also known as INK4a and CDKN2A (1-2) is a cyclin-dependent kinase inhibitor that specifically inhibits CDK4 and CDK6. Disruption of cyclin-CDK4 complex by p16 prevents phosphorylation of Rb, therefore preventing cell cycle progression from the G1 to S phase (3-4). p16 suppresses cell growth in response to intracellular stimuli. p16 is also know as an important tumor suppressor. Mutations and deletions in p16 have been detected in a wide variety of tumors, especially in Melanoma (5).
Related PathwayDruggable Genome Cell cyclep53 signaling pathwayPathways in cancerPancreatic cancerGliomaMelanomaMore Pathways >>

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* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - p16 INK4a antibody [EP435Y]; Anti-CDKN2A/p16INK4a antibody [EP435Y] at 1/2000 dilution + 293 cell lysate at 10 ug.Predicted band size : 17 kDa.Observed band size : 17 kDa.
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