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Anti-TRAF6 Antibody EP592Y
Also for TRAF6 (NM_145803)
|A synthetic peptide corresponding to residues in the C-term of human TRAF6 was used as immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:500~1000; ICC: 1:250-500
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6), transcript variant 1|
|Tumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family member that participates in signal transduction of both the TNF receptor superfamily and the interleukin-1 receptor /Toll-like receptor superfamily. Acting as an adapter protein and a signal transducer, TRAF6 links members of the TNF receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. (1-2). TRAF6 stimulates NFkB through interaction with CD40, TNFR, IL-1R, p75 NTR, and TRANCE receptor. Additionally, o verexpression of TRAF6 is sufficient to activate signaling pathways leading to NF-B and AP-1 in the absence of extracellular stimuli (3-5). |
MAPK signaling pathway
Toll-like receptor signaling pathway
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Western blot - TRAF6 antibody [EP592Y]; Anti-TRAF6 antibody [EP592Y] at 1/2000 dilution + 10ug Jurkat cell lysate.Predicted band size : 63 kDa.Observed band size : 58 kDa .
Immunocytochemistry/ Immunofluorescence - TRAF6 antibody [EP592Y]; ab40675 at a 1:250 dilution; Immunofluorescent staining of Hela cells using anti-TRAF6 RabMAb.