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Anti-TRAF6 Antibody EP592Y


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against TRAF6 (Clone EP592Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403440) , 20ug Explanation
100ul $325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues in the C-term of human TRAF6 was used as immunogen.
Clone NameEP592Y IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:500~1000; ICC: 1:250-500
Predicted MW Explanation 63 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Tissue culture supernatant

Reference Data

Target NameHomo sapiens TNF receptor-associated factor 6, E3 ubiquitin protein ligase (TRAF6), transcript variant 1
Alternative NameMGC:3310; RNF85
Database LinkNP_665802
Entrez Gene 7189 Human
Entrez Gene 22034 Mouse
Entrez Gene 311245 Rat
FunctionTumour-necrosis factor (TNF) receptor-associated factor 6 (TRAF6) is the only TRAF family member that participates in signal transduction of both the TNF receptor superfamily and the interleukin-1 receptor /Toll-like receptor superfamily. Acting as an adapter protein and a signal transducer, TRAF6 links members of the TNF receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. (1-2). TRAF6 stimulates NFkB through interaction with CD40, TNFR, IL-1R, p75 NTR, and TRANCE receptor. Additionally, o verexpression of TRAF6 is sufficient to activate signaling pathways leading to NF-B and AP-1 in the absence of extracellular stimuli (3-5).
Related PathwayDruggable Genome MAPK signaling pathwayUbiquitin mediated proteolysisEndocytosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - TRAF6 antibody [EP592Y]; Anti-TRAF6 antibody [EP592Y] at 1/2000 dilution + 10ug Jurkat cell lysate.Predicted band size : 63 kDa.Observed band size : 58 kDa .
Immunocytochemistry/ Immunofluorescence - TRAF6 antibody [EP592Y]; TA300591 at a 1:250 dilution; Immunofluorescent staining of Hela cells using anti-TRAF6 RabMAb.


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