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Anti-RHOA Antibody EP487Y
Also for RHOA (NM_001664)
|A synthetic peptide corresponding to residues near the N-term of human Rho was used as immunogen. The antibody is predicted to detect RhoA, RhoB and RhoC based on sequence analysis.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:2,000-10,000; IHC: 1: 100-250; ICC: 1:250-500; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Homo sapiens ras homolog family member A (RHOA)|
|ARH12; ARHA; RHO12; RHOH12|
|Rho belongs to the Ras super family of low molecular weight GTPases. Fifteen Rho proteins have already been characterized and divided into three sub-families; the first includes Rho (A, B, C), the second, Rnd 1-3 and the third which includes Rac 1-3, RhoG, Cdc42Hs, Rho/TTF. TC10 and Chp (1-2). Rho acts as a molecular switch which turns on of off various intracellular signaling pathways such as ACK, PAKs, MEKKs ROCK (3). Rho is active when bound to GTP and inactive when bound to GDP (4). It is also known to participate in many physiological activities including cell migration, adhesion, cytokinesis, proliferation, differentiation and apoptosis and to a greater extend cell transformation (5). |
Signaling by GPCR
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot - Rho antibody [EP487Y]; Anti-Rho antibody [EP487Y] + 10ug HL60 cell lysate.Predicted band size : 21 kDa.Observed band size : 22 kDa .
Immunohistochemistry (Paraffin-embedded sections) - Rho antibody [EP487Y]; ab40673 at a 1:100 dilution staining Rho in human prostate carcinoma tissue.