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Home Antibody All anti-MAP2K4 antibodies

Anti-MAP2K4 Antibody EP559Y

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA300572
  • Rabbit Monoclonal Antibody against MAP2K4 (Clone EP559Y)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401058) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)
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Also for MAP2K4 (NM_003010)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the N-term of human MKK4 was used as immunogen.
Clone NameEP559Y IsotypeIgG
Species ReactivityHuman, Rat ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1:500-2,000; IHC: 1:50-100; ICC: 1:250-500; IP: 1:50
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens mitogen-activated protein kinase kinase 4 (MAP2K4), transcript variant 1
Alternative NameJNKK; JNKK1; MAPKK4; MEK4; MKK4; PRKMK4; SAPKK-1; SAPKK1; SEK1; SERK1; SKK1
Database LinkNP_003001
FunctionMKK4, also known as JNKK1 and SEK1, is a dual specificity kinase that belongs to the Ser/Thr protein kinase family. MKK4 is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MKK4 phosphorylate and activate p38 MAP kinase and JNK but not ERK 1/2 (1-2). JNK is activated by dual phosphorylation at Thr and Tyr by MKK4 and MKK7; although MKK4 will preferentially phosphorylate Tyr (3). MKK4 is also known to be a tumor suppressor, as mutations inactivating the MKK4 gene have been found in 5% of a wide variety of tumor types (4).
Related Pathway
Apoptosis
MAPK signaling pathway
Toll-like receptor signaling pathway

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WB Image
Western blot - SEK1 / MKK4 antibody [EP559Y]; Anti-MEK4 antibody [EP559Y] at 1/2000 dilution + Hela cell lysate.Predicted band size : 44 kDa.Observed band size : 44 kDa.Additional bands at : 62 kDa. We are unsure as to the identity of these extra bands.
IHC Image
Immunohistochemistry (Paraffin-embedded sections) - SEK1 / MKK4 antibody [EP559Y]; TA300572, at a 1/50 dilution, staining human breast carcinoma by Immunohistochemistry, Paraffin embedded tissue.
IF Image
Immunofluorescence - SEK1 / MKK4 antibody [EP559Y]; TA300572, staining Hela cells by Immunofluorescent

 

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