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Anti-ITK Antibody Y402

WB(1)

Gene Name Homo sapiens IL2-inducible T-cell kinase (ITK) Synonyms: EMT; LYK; PSCTK2 Immunogen A synthetic peptide corresponding to residues near the C-term of human Emtk/Itk/Tsk was used as immunogen. Buffer 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Clone Name Y402 Isotype IgG Species Reactivity Human Concentration Purification (Protein A or G Sepharose) Guaranteed Application * WB Suggested Dilutions WB: 1: 1,000; FC: 1:50; IP: 1:50 Background Emtk/Itk/Tsk is a member of the Tec family of Protein Tyrosine Kinase (PTK) expressed in T, NK, and mast cells (1). Structurally, Emtk/Itk/Tsk possesses a tyrosine kinase (TK), a pleckstrin homology (PH) and a TEC homology domain. It also contains both SRC homology 2 (SH2) and a SRC homology 3 (SH3) domains (2). It lacks as well the amino-terminal myristylation signal and the negative autoregulatory phosphorylation site present in all members of the Src family of PTKs (3). Additionally, the Src tyrosine kinase LCK is required for Emtk/Itk/Tsk activation and recruitment by CD28 (4). Related Pathway

Related Lysate from OriGene • Transient overexpression lysate of IL2-inducible T-cell kinase (ITK) Anti-Tag Antibodies & WB Reagent • Anti-Tag Antibodies • Western Blot Reagent shRNA • ITK - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector • ITK - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector • Itk - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector • ITK - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector • Itk - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector Related ORF Clones • Myc-DDK-tagged ORF clone of Homo sapiens IL2-inducible T-cell kinase (ITK) as transfection-ready DNA • Lenti ORF clone of Human IL2-inducible T-cell kinase (ITK) , Myc-DDK-tagged • Lenti ORF clone of Human IL2-inducible T-cell kinase (ITK), mGFP tagged • GFP-tagged ORF clone of Homo sapiens IL2-inducible T-cell kinase (ITK) as transfection-ready DNA • Myc-DDK-tagged ORF clone of Homo sapiens IL2-inducible T-cell kinase (ITK) as 200 ug transfection-ready DNA Related cDNA Clones • Homo sapiens IL2-inducible T-cell kinase (ITK) as transfection-ready DNA • Kinase deficient mutant (K391M) of Homo sapiens IL2-inducible T-cell kinase (ITK) as transfection-ready DNA

Conjugation Services
OriGene provides conjugation services of TrueMAB antibodies with the following molecules:

• HRP
• Biotin
• PE
• FITC
• DyLight® 488
• DyLight® 550
• DyLight® 594
• DyLight® 633

* DyLight is a trademark of Thermo-Fisher Scientific

Bulk Order
OriGene offers bulk sizes of TrueMAB antibodies in both the BSA/glycerol formulation and the carrier-free (BSA/glycerol-free) formulation.

Contact us with your conjugation/bulk request: antibody@origene.com or 888-267-4436 (Tech Support)