Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS)
ALPS4; N-ras; NRAS1; NS6
A synthetic peptide corresponding to residues in the effector region of human Ras was used as an immunogen. Predicted to react with other Ras family members and cross-react with most species based on sequence homology.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Ras, a signal transducer, was first characterized as the transforming genes of Harvey & Kristen sarcoma virus (1). The Ras family (H-Ras, N-Ras, and K-Ras) regulates cell growth, differentiation and apoptosis (2). Switching from an active or resting state, Ras can either bind GTP or GDP respectively. In the triphosphate conformation, Ras will interact with GTPase activating protein (GAP) to increase its activity (3). Mutations in any of the three isoforms can convert these proteins into active oncogenes. Additionally, Ras mutations are found in 30 % of all human cancer (4).
EGFR1 Signaling Pathway
MAPK signaling pathway
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