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Anti-CHEK2 Antibody Y171


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against CHEK2 (Clone Y171)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC416128) , 20ug Explanation
100ul $325 3-7 Days
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Also for CHEK2 (NM_007194)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Threonine 68 of human Chk2 was used as immunogen. The antibody will detect Chk2 phosphorylation on Threonine 68. This antibody may also detect all splice isoforms (2-12) based on sequence h
Clone NameY171 IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, DB Suggested DilutionsWB: 1: 1,000-5,000; IP: 1:50
Predicted MW Explanation 61 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Purification Whole Cell Lysate
Note Does not react with Mouse, Rat

Reference Data

Target NameHomo sapiens checkpoint kinase 2 (CHEK2), transcript variant 1
Alternative NameCDS1; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53
Database LinkNP_009125
Entrez Gene 11200 Human
FunctionChk2 is a checkpoint kinase that plays a role in regulating cell cycle progression. In response to DNA damage and DNA replicational stress, Chk1 and Chk2 phosphorylate Cdc25C to prevent entry into mitosis (1,2). Consisting of ionizing radiation (IR), UV irradiation or hydroxyurea treatment, DNA damage induces ATM/ATR to phosphorylate Thr68 and other sites in the amino terminal domain (3). Phosphorylation at Thr68 is a prerequisite for subsequent activation steps.
Related PathwayProtein KinaseStem cell - PluripotencyDruggable Genome Cell cyclep53 signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot - Chk2 (phospho T68) antibody [Y171]; All lanes : Anti-Chk2 (phospho T68) antibody [Y171] at 1/1000 dilution.Lane 1 : 293 cell lysate.Lane 2 : 293 cell lysate treated with 2uM Doxorubicin.Lane 3 : 293 cell lysate treated with 10uM Doxorubicin.Predicted band size : 61 kDa.Observed band size : 62 kDa .
Dot Blot - Chk2 (phospho T68) antibody [Y171]; Dot Blot analysis on immunogen phospho-peptide (A) and non-phospho peptide (B) using anti-Phospho-Chkr2 (pT68) RabMAb dilution 1:500


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