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Anti-MAP2K1IP1 Antibody Y130
Also for MAP2K1IP1 (NM_021970)
|A synthetic peptide corresponding to residues in the C-terminus of human mitogen-activated protein kinase kinase 1 interacting protein 1 was used as immunogen.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1000; IHC: 1: 100-250; ICC: 1:50-100; IP: 1:50
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|IgG fraction (Protein A or G Sepharose)
|Does not react with Rat
|Homo sapiens late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 (LAMTOR3), transcript variant 1|
|MAP2K1IP1; MAPBP; MAPKSP1; MP1; PRO0633; Ragulator3|
|The function of MP1 (MEK partner-1) a 14kDa scaffold protein, is to bind specifically to MEK1 and ERK1 and bring them in close proximity in order to facilitate their activation (1). Localized to the late endosome, MP1 also interacts with an adaptor protein p14. While the interaction between MP1-ERK1 can take place in the absence of the adaptor protein p14, it is strengthened in the presence of p14 (2). Additionally, it has been suggested that the binding of MP1 to MEK1resides in a proline-rich sequence (residue 270-307) of MEK1 |
MAPK signaling pathway
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Western blot - MAP2K1IP1 antibody [Y130]; Anti-MAP2K1IP1 antibody [Y130] at 1/50000 dilution + A431 cell lysate.Observed band size : 14 kDa .
Immunohistochemistry (Paraffin-embedded sections) - MAP2K1IP1 antibody [Y130]; ab32134, staining human breast carcinoma by immunohistochemistry, Paraffin embedded tissue
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MAP2K1IP1 antibody [Y130]; ab32134 showing positive staining in Breast carcinoma tissue.