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Anti-GRIA1 Antibody E308
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Also for GRIA1 (NM_000827)
|A synthetic peptide corresponding to residues near N-terminus of human Glutamate receptor 1 was used as immunogen. Predicted to cross-react with rat, based on sequence homology.|
||WB: 1: 1000; IHC: 1:50; IP: 1:30
|50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Homo sapiens glutamate receptor, ionotropic, AMPA 1 (GRIA1), transcript variant 1|
|GluA1; GLUH1; GLUR1; GLURA; HBGR1|
|Glutamic acid is the major excitatory neurotransmitter in the mammalian central nervous system. Glutamate receptors are classified on the basis of their activation by different agonists (1-3). GluR1, human glutamate receptor type 1, is an integral membrane protein that is widely expressed in the human brain. The postsynaptic actions of glutamic acid are mediated by a variety of receptors that are named according to their selective agonists. GluR1 is known to bind a kainate subtype of agonist. It has been found that malfunctioning of the glutamatergic system may result in certain brain disorders and neurodegeneration (3).|
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Western blot analysis on SH-SY5Y cell lysate using anti-GluR1, dilution 1:1,000.
Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-GluR1.