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Anti-STAT3 Antibody E121-21
Also for STAT3 (NM_213662)
|A synthetic peptide corresponding to residues surrounding Ser727 of human Stat3 was used as immunogen. The antibody only detects Stat3 without phosphorylation on Serine 727. It does not detect S727-phosphorylated Stat3. Predicted to cross-react with bovine, and horse, based on sequence homology.|
|Human (Does not react with: Mouse, Rat)
||Lot dependent; please refer to CoA along with shipment
||IHC-Fr: Use at an assay dependent concentration; WB: 1:1000; IHC-P: Use at an assay dependent dilution; IP: 1:20
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Protein A purified
|Is unsuitable for Flow Cyt.
|Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3|
|Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3-activated transcription seems to be regulated by serine phosphorylation at Ser727 (4).|
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
TGF Beta Signaling Pathway
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Western blot - STAT3 antibody [E121-21]; Anti-STAT3 antibody [E121-21] at 1/1000 dilution + A431 cell lysate.Predicted band size : 88 kDa.Observed band size : 92 kDa .
Immunohistochemistry (Paraffin-embedded sections) - STAT3 antibody [E121-21]; Immunohistochemical analysis of paraffin-embedded lung squamous carcinoma using TA300380 at a 1/50 dilution.