Homo sapiens cAMP responsive element binding protein 1 (CREB1), transcript variant B
Synonyms:
CREB
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Ser133 of human CREB was used as immunogen. The antibody only detects CREB phosphorylated on Serine 133. Predicted to cross-react with bovine, chicken, and zebra fish, based on sequence hom
Buffer
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
CREB is a transcription factor protein that binds the cAMP response element (CRE), thereby stimulating transcription of this sequence. CREB plays a role in propagating numerous extracellular signals to the nuclues (1-3). CREB is activated by phosphorylation at the Ser133 position by various signaling pathways, and some of the kinases involved in phosphorylating CREB at Ser133 are p90RSK, MSK, CaMKIV and MAPKAPK-2 (1-3).
Related Pathway
Adipogenesis
EGFR1 Signaling Pathway
Melanogenesis
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Western blot analysis on A431 cell lysate using anti-Phospho-CREB (pS133), 1:500 dilution. Cells were either (1) untreated or (2) treated with Forskolin.
Immunohistochemical staining of untreated (A) and Phosphatase-treated (B) paraffin-embedded thyroid gland adenocarcinoma using anti-Phospho-CREB (pS133)
