Anti-Stat5a Antibody, clone 4H1

Also for Stat5a (NM_003152)

Gene Name	Homo sapiens signal transducer and activator of transcription 5A (STAT5A)
Synonyms:	MGF; STAT5
Immunogen	Human recombinant protein fragment corresponding to amino acids 2-104 of human Stat5a (NP_003143) produced in E.coli.
Buffer	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Clone Name	clone 4H1	Isotype	IgG1
Species Reactivity	Human, Rat	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB 1:200~500, IHC 1:50,
Background	Stat5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
Related Pathway	Adipogenesis EGFR1 Signaling Pathway Jak-STAT signaling pathway

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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-Stat5a monoclonal antibody.

STAT5a antibody ( 4H1) at 1:500 dilution + lysate from 293T cells transfected with human Stat5a expression vector (Cat# RC205753)

Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Human lung tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Human thyroid tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-Stat5a mouse monoclonal antibody. (TA500006)

Anti-Stat5a TrueMAB Antibody clone 4H1