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Anti-STAT2 Antibody


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SKU Description Amount Price Availability*  
  • Rabbit polyclonal STAT2 phospho Y690 antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417313) , 20ug Explanation
100ug $325 3-7 Days
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Also for STAT2 (NM_005419)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenThis affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminus of human STAT2 protein.
Clone Name IsotypeIgG
Species Reactivityhuman, chimpanzee, macaque, Vervet monkey, rat, dog, pig, horse, mouse, bovine Concentration1.15 mg/mL
Guaranteed Application *WB Suggested DilutionsELISA: 1:85,000, WB: 1:500 – 1:1000
Buffer0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Note This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. STAT2 is a member of the STAT family of transcription factors.  Unlike other STATs, STAT2 is unique as it can only be activated by interferons (IFNs). STAT2 is a critical component in mediating many IFN-stimulated biological activities including antiproliferation and antiviral responses. Upon IFN treatment, STAT1 and STAT2 become tyrosine phosphorylated, assemble as heterodimers that bind IRF9 to form the ISGF3 complex.  This complex translocates to the nucleus, binds to promoters of IFN-stimulated genes and mediates gene transcription.  Consequently, mutations in STAT2 or loss of STAT2 expression leads to impairment in IFN signal transduction and gene activation.  IFN-alpha is an approved drug for the treatment of several forms of cancer. Yet only a subset of patients who receive IFN-alpha therapy benefit from the treatment.  Given that STAT2 is activated by IFNs, it is important to define if the reduced or lack of antitumor effects seen in cancer patients on IFN therapy is due to in defects in STAT2 function. Our goal is to identify regions/motifs within the structural domains of STAT2 that not only are essential for the tyrosine phosphorylation of STAT2, but also regulate the antitumor effects of IFN-alpha.  Collectively, the results of our studies will emphasize the physiological role of STAT2 in cancer.  From a clinical viewpoint, cancer patients who may benefit the most from receiving IFN-alpha therapy can be selected based on their STAT2 function.

Reference Data

Target NameHomo sapiens signal transducer and activator of transcription 2, 113kDa (STAT2), transcript variant 1
Alternative NameISGF-3; P113; STAT113
Database LinkNP_005410
Entrez Gene 6773 Human
Entrez Gene 20847 Mouse
Entrez Gene 288774 Rat
Entrez Gene 712694 Monkey
Entrez Gene 481111 Dog
Related PathwayTranscription FactorsDruggable Genome Chemokine signaling pathwayJak-STAT signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot using Immuno-chemicals affinity purified anti-Stat2pY690 antibody shows detection of Stat2pY690 protein (arrowhead) in Jurkat cells without (left lane) and with (right lane) 1000U/mL of IFN-a for 15 min at 37oC. Primary antibody was used at 1:1,000.  Personal Communication, A.Gamero, NCI, Bethesda, MD.


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