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Home Antibody All anti-SPHK1 antibodies

Anti-SPHK1 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA305846 Goat Anti-SPHK1 Antibody 100ug $325 3-7 Days
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OriGene Data

ImmunogenPeptide with sequence C-DVDLESEKYRRLGE, from the internal region of the protein sequence according to NP_068807.2; NP_892010.1.
Clone Name IsotypeGoat IgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Rat, Dog, Cow Concentration0.5 mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 2-3ug/ml.
Buffer0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.

Reference Data

Target NameHomo sapiens sphingosine kinase 1 (SPHK1), transcript variant 3
Alternative NameSPHK
Database LinkNP_001136073
Entrez Gene 8877 Human
Entrez Gene 20698 Mouse
Entrez Gene 170897 Rat
Entrez Gene 483329 Dog
FunctionSphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for EDG1 (MIM 601974). Various stimuli increase cellular levels of SPP by activation of sphingosine kinase (SPHK), the enzyme that catalyzes the phosphorylation of sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including platelet-derived growth factor (e.g., MIM 173430) and serum.[supplied by OMIM].
Related PathwayDruggable Genome Sphingolipid metabolismMetabolic pathwaysCalcium signaling pathwayVEGF signaling pathwayFc gamma R-mediated phagocytosis

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

TA305846 (2ug/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.


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