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Anti-SOX2 Antibody EPR3131
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Also for SOX2 (NM_003106)
|A synthetic peptide corresponding to residues in human SOX2 was used as an immunogen.|
||ICC: 1:50 - 100, IHC: 1:100 - 250, WB: 1:5,000 - 20,000,
|Store at -20C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.|
|Homo sapiens SRY (sex determining region Y)-box 2 (SOX2)|
|SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach (1). SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression (2). |
Wnt Signaling Pathway
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Western blot analysis on (A) NCCIT and (B) MCF-7 cell lysates using anti-SOX2 RabMAb .
Immunohistochemical analysis of paraffin-embedded human adult brain tissue using anti-SOX2 RabMAb .