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Home Antibody All anti-SOCS3 antibodies

Anti-SOCS3 TRUEMAB Antibody Clone OTI6F3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA502922 SOCS3 mouse monoclonal antibody, clone OTI6F3 (formerly 6F3) 100ul $325 In Stock
LC401300 SOCS3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF502922 Carrier-free (BSA/glycerol-free) SOCS3 mouse monoclonal antibody, clone OTI6F3 (formerly 6F3) 100ug $450 8-10 Days
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WB(1)
FC(2)
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Also for SOCS3 (NM_003955)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human SOCS3 (NP_003946) produced in HEK293T cell.
Clone NameClone OTI6F3 IsotypeIgG1
Species ReactivityHuman Concentration0.76 mg/ml
Guaranteed Application *WB, FC Suggested DilutionsWB 1:500, FLOW 1:100
Predicted MW Explanation 24.6 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens suppressor of cytokine signaling 3 (SOCS3)
Alternative NameATOD4; CIS3; Cish3; SOCS-3; SSI-3; SSI3
Database LinkNP_003946
Entrez Gene 9021 Human
FunctionThis gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene is induced by various cytokines, including IL6, IL10, and interferon (IFN)-gamma. The protein encoded by this gene can bind to JAK2 kinase, and inhibit the activity of JAK2 kinase. Studies of the mouse counterpart of this gene suggested the roles of this gene in the negative regulation of fetal liver hematopoiesis, and placental development. [provided by RefSeq].
Related PathwayDruggable Genome Ubiquitin mediated proteolysisJak-STAT signaling pathwayInsulin signaling pathwayAdipocytokine signaling pathwayType II diabetes mellitus

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SOCS3 (RC209305, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SOCS3.
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HEK293T cells transfected with either RC209305 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-SOCS3 antibody(TA502922), and then analyzed by flow cytometry.
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Flow cytometric Analysis of Hela cells, using anti-SOCS3 antibody(TA502922),(Red), compared to a nonspecific negative control antibody(TA50011),(Blue).
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