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Anti-SOCS2 Antibody EPR2588(2)
Also for SOCS2 (NM_003877)
|A synthetic peptide corresponding to residues near the N-terminus of human SOCS2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000; IP: 1:10 - 1:100; ICC/IF: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens suppressor of cytokine signaling 2 (SOCS2), transcript variant 1|
|CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2|
|SOCS2 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of SOCS2 can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. SOCS2 is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control (1).|
Jak-STAT signaling pathway
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Western blot - SOCS2 antibody [EPR2588(2)]; All lanes : Anti-SOCS2 antibody [EPR2588(2)] at 1/1000 dilution.Lane 1 : MCF7 cell lysate.Lane 2 : NCCIT cell lysate.Lane 3 : K562 cell lysate.Lysates/proteins at 10 µg per lane.Predicted band size : 22 kDa.
Immunocytochemistry/ Immunofluorescence - SOCS2 antibody [EPR2588(2)]; Immunofluorescent staining of HeLa cells using ab109245 at 1/100 dilution.