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Anti-SNCA PHOSPHO Antibody EPR2179(2)


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SKU Description Amount Price Availability*  
TA310862 Rabbit Monoclonal antibody against Alpha-Synuclein, pY125 (SNCA) (Phospho-specific) 100ul $325 In Stock
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OriGene Data

ImmunogenA phospho specific peptide corresponding to residues surrounding tyrosine 125 of human Alpha-Synuclein was used as an immunogen. This antibody only detects Alpha-Synuclein phosphorylated at tyrosine 125.
Clone NameEPR2179(2) IsotypeIgG
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt,IHC-P or IP.

Reference Data

Target NameHomo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1
Alternative NameNACP; PARK1; PARK4; PD1
Database LinkNP_000336
Entrez Gene 6622 Human
FunctionAlpha-Synuclein is expressed predominantly in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3).
Related PathwayDruggable Genome Alzheimer's diseaseParkinson's disease

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WB Image
Western blot - Anti-alpha Synuclein (phospho Y125) antibody [EPR2179(2)]; All lanes : Anti-alpha Synuclein (phospho Y125) antibody [EPR2179(2)] at 1/1000 dilution.Lane 1 : HeLa cell lysates, untreated .Lane 2 : HeLa cell lysates, treated with pervanadate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 14 kDa.


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