Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) (SNCA), transcript variant 1
Synonyms:
NACP; PARK1; PARK4; PD1
Immunogen
A phospho specific peptide corresponding to residues surrounding tyrosine 125 of human Alpha-Synuclein was used as an immunogen. This antibody only detects Alpha-Synuclein phosphorylated at tyrosine 125.
Buffer
Store at -20 °C. Buffer: Antibody buffer, sodium azide, glycerol, and BSA. Stable for 12 months from date of receipt.
Alpha-Synuclein is expressed predominantly in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3).
Related Pathway
EGFR1 Signaling Pathway
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Western blot analysis on HeLa cell lysates using anti-Phospho-Alpha-Synuclein (pY125) RabMAb. Cells were either (A) untreated (B) treated with pervanadate.
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