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OriGene Antibodies in recent publications
A common polymorphism in the LDL receptor gene has multiple effects on LDL receptor function Hum. Mol. Genet., Apr 2013; 22: 1424 - 1431. [anti-DDK]
Excitotoxicity Upregulates SARM1 Protein Expression and Promotes Wallerian-Like Degeneration of Retinal Ganglion Cells and Their Axons Invest. Ophthalmol. Vis. Sci., Apr 2013; 54: 2771 - 2780. [SARM1]
Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX Nature 497, 122-126 doi:10.1038/nature12052 [anti-DDK]
Natriuretic Peptide Receptor-3 Gene (NPR3): Nonsynonymous Polymorphism Results in Significant Reduction in Protein Expression Because of Accelerated Degradation Circ Cardiovasc Genet, Apr 2013; 6: 201 - 210. [NPR3]
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 Home All anti-SMAD5 antibodies

Anti-SMAD5 Antibody EP619Y

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Specifications Related Products Conjugation/Bulk FAQs
SKU Description Amount Price Availability*  
TA300604
  • Rabbit Monoclonal Antibody against SMAD5 (Clone EP619Y)
  • FREE positive control: HEK293T cell transient overexpression lysate (LC416990) , 20ug
 100µl $325 3-7 Days Add to Shopping Cart
WB(1)
Gene NameHomo sapiens SMAD family member 5 (SMAD5), transcript variant 1
Synonyms:DWFC; JV5-1; MADH5
ImmunogenA synthetic peptide corresponding to residues near the MH2 domain of human Smad 5 was used as immunogen.
Buffer50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Clone NameEP619Y IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration
Guaranteed Application *WB Suggested DilutionsWB: 1: 1,000; ICC: 1:50; FC: 1:30
BackgroundSmad 5 is a member of the Mothers Against Dpp (MAD)-related family of proteins. So far, eight Smads have been identified and can be divided into 3 subgroups based on their structure and function; pathway-restricted, common mediator and inhibitory. Smad 1, 5 and 8 serve as pathway-restricted Smads for the bone morphogenetic proteins (BMPs) signaling pathway (1). Smad 5 is directly activated by BMP type Ia or Ib receptors upon BMP-2 stimulation and transduced BMP-2 signals to the nucleus by forming a complex with Smad 4 (2-3).
Related Pathway
TGF Beta Signaling Pathway

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WB Image
Western blot analysis on Cos-1 cell lysate using anti-Smad 5, dilution 1:1,000.

 

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