Home Antibody All anti-SLPI antibodies
Also for SLPI (NM_003064)
|SLPI antibody was raised against a 17 amino acid peptide from near the center of human SLPI.|
||Lot dependent; please refer to CoA along with shipment
||WB: 0.5 - 1 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens secretory leukocyte peptidase inhibitor (SLPI)|
|ALK1; ALP; BLPI; HUSI; HUSI-I; MPI; WAP4; WFDC4|
Entrez Gene 6590 Human
Entrez Gene 20568 Mouse
|Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kB activation by inhibiting IkB degradation in the cytoplasm and competing for NF-kB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.|
|Secreted Protein |
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Western blot analysis of SLPI in Daudi cell lysate with SLPI antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry of SLPI in mouse lung tissue with SLPI antibody at 10 ug/ml.
IHC staining by using anti-SLPI antibody indicates increased production of SLPI by 4T1.2 cells. (A). Staining of cell pellets of 4T1 and 4T1.2 cells grown in vitro shows that almost all 4T1.2 cells produce SLPI whereas production by 4T1 cells is confined to a subpopulation of cells. (B). Staining of mice breast tumors derived from the injection of 4T1 and 4T1.2 cells also demonstrates a stronger and more uniform staining of SLPI in the 4T1.2 tumors. Dilution: 1:7500