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Home Antibody All anti-SKI antibodies

Anti-SKI Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306035
  • Rabbit Polyclonal Ski Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC418933) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenSki antibody was raised against a 14 amino acid peptide from near the amino terminus of human Ski.
Clone Name IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens v-ski avian sarcoma viral oncogene homolog (SKI)
Alternative NameSGS; SKV
Database LinkNP_003027
Entrez Gene 6497 Human
FunctionTGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Ski in human kidney tissue lysate with Ski antibody at (A) 1 and (B) 2 ug/mL.
IF Image
Immunofluorescence of Ski in human kidney tissue with Ski antibody at 20 ug/mL.

 

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