Homo sapiens single-minded homolog 1 (Drosophila) (SIM1)
Synonyms:
bHLHe14
Immunogen
Peptide with sequence C-SGDRYRTEQYQS, from the internal region of the protein sequence according to NP_005059.2.
Buffer
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Clone Name
Isotype
Species Reactivity
Human, Mouse, Rat, Dog, Cow, porcine
Concentration
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. (Protein A or G Sepharose)
Guaranteed Application *
WB
Suggested Dilutions
WB: 1-3ug/ml
Background
SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. SIM1 transcript was detected only in fetal kidney out of various adult and fetal tissues tested. Since the sim gene plays an important role in Drosophila development and has peak levels of expression during the period of neurogenesis,it was proposed that the human SIM gene is a candidate for involvement in certain dysmorphic features (particularly the facial and skull characteristics), abnormalities of brain development, and/or mental retardation of Down syndrome. [provided by RefSeq].
Related Pathway
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