SIGLEC15 Rabbit Polyclonal Antibody

CAT#: TA320161

Rabbit Polyclonal SIGLEC15 Antibody

Product Images

Western blot analysis of SIGLEC15 in Rat kidney tissue lysate with SIGLEC15 antibody at (A) 1 and (B) 2 ug/mL

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  Immunohistochemistry of SIGLEC15 in human kidney tissue with SIGLEC15 antibody at 2.5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SIGLEC15 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SIGLEC15.
• Formulation: SIGLEC15 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: SIGLEC15 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sialic acid binding Ig like lectin 15
• Database Link:
  NP_998767
  Entrez Gene 498888 RatEntrez Gene 620235 MouseEntrez Gene 284266 Human
  UniProt ID Q6ZMC9
• Background: SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.
• Synonyms: CD33L3; HsT1361; SIGLEC-15

Reference Data

• Protein Families: Transmembrane