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Anti-SFRP2 Antibody EPR4832
Also for SFRP2 (NM_003013)
|A synthetic peptide corresponding to residues in human SFRP2 was used as an immunogen.|
|Human, Mouse, Rat
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:1000 - 1:10000
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant (Protein A or G Sepharose)
|Is unsuitable for Flow Cyt,ICC,IHC-P or IP.
|Homo sapiens secreted frizzled-related protein 2 (SFRP2)|
|FRP-2; SARP1; SDF-5|
|SFRP’s (Secreted Frizzled Related Proteins) function as soluble modulators of Wnt signaling. SFRP2 is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. (1). It has a role in regulating cell growth and differentiation in specific cell types. Another function of SFRP2 is to regulate procollagen processing by binding to Tolloid metalloproteinases; it also interacts with an integrin-fibronectin complex modulating apoptosis (2). SFRP2 may be important for eye retinal development and for myogenesis (3). In addition, methylation of SFRP2 is a potential marker for the presence of colorectal cancer (1).|
Wnt Signaling Pathway
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Western blot - SFRP2 antibody [EPR4832]; All lanes : Anti-SFRP2 antibody [EPR4832] at 1/1000 dilution.Lane 1 : U87-MG cell lysate.Lane 2 : HUVEC cell lysate.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled goat anti-rabbit. at 1/2000 dilution.Predicted band size : 33 kDa.