SF3A1 is subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. SF3A1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. It has tandemly repeated SURP motifs in its amino-terminal half, while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated SF3A1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3, while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs (1).
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