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Anti-SCRIB Antibody EPR4140(2)


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal antibody against Scribble (SCRIB)
100ul 325 3-7 Days
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OriGene Data

ImmunogenA synthetic peptide corresponding to residues near the C-terminus of human Scribble was used as an immunogen.
Clone NameEPR4140(2) IsotypeTissue culture supernatant
Species ReactivityHuman (Does not react with: Mouse, Rat) ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, FC Suggested DilutionsWB: 1:1000 - 1:10000; ICC: 1:100 - 1:250; FC: 1:100 - 1:500
BufferpH: 7.40Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA
Note Is unsuitable for IHC-P or IP.

Reference Data

Target NameHomo sapiens scribbled planar cell polarity protein (SCRIB), transcript variant 2
Alternative NameCRIB1; SCRB1; SCRIB1; Vartul
Database LinkNP_056171
Entrez Gene 23513 Human
FunctionScribble is a cytoplasmic multimodular scaffold protein targeted to epithelial adherens junctions and neuronal presynaptic compartments. Scribble and its orthologs in vertebrates and invertebrates participate in cell polarization (1). It may regulate cell invasion through MAPK signaling. Scribble functions as an activator of Rac GTPase activity (2). Deficiency in Scribble impairs many aspects of cell polarity and cell movement (1).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot - Anti-SCRIBBLE antibody [EPR4140(2)]; All lanes : Anti-SCRIBBLE antibody [EPR4140(2)] at 1/1000 dilution.Lane 1 : 293T cell lysate.Lane 2 : HeLa cell lysate.Lane 3 : MCF7 cell lysate.Lysates/proteins at 10 ug per lane.Secondary.Goat anti-Rabbit HRP at 1/2000 dilution.Predicted band size : 175 kDa.
FC Image
Flow Cytometry - Anti-SCRIBBLE antibody [EPR4140(2)]; TA311056 at 1/100, staining SCRIBBLE in permeabilized 293T cells by flow cytometry (red), compared with a negative control Rabbit IgG antibody (green).


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