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Home Antibody All anti-S100A12 antibodies

Anti-S100A12 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA301490
  • Rabbit Polyclonal Antibody against S100A12
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401723) , 20ug
100ul 325 3-7 Days
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WB(1)
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Also for S100A12 (NM_005621)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human S100A12 protein [Swiss-Prot# P80511] expressed in E. coli.
Clone Name IsotypeIgG
Species Reactivityhuman not mouse or rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB Suggested DilutionsWB: 1: 1000
Buffer0.1% sodium azide
Purification Whole antisera

Reference Data

Target NameHomo sapiens S100 calcium binding protein A12 (S100A12)
Alternative NameCAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6
Database LinkNP_005612
FunctionS100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
Related Pathway

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Detection of S100A12 in HeLa whole cell extracts

 

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