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Home Antibody All anti-RPTOR antibodies

Anti-RPTOR Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306211
  • Rabbit Polyclonal Raptor Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenRaptor (CT) polyclonal antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of mouse Raptor.
Clone Name IsotypeIgG
Species ReactivityMouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsWB: 2-4ug/ml; ICC: 10ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameMus musculus regulatory associated protein of MTOR, complex 1 (Rptor)
Alternative Name4932417H02Rik; mKIAA1303; Rap; Raptor
Database LinkNP_083174
Entrez Gene 74370 Mouse
FunctionThe mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1). Rapamycin inhibits TOR activity resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation (reviewed in 2). Raptor (regulatory associated protein of TOR) is a TOR-binding protein essential for TOR signaling in vivo. It acts as a TOR scaffold protein whose binding by TOR substrates is necessary for effective TOR-catalyzed phosphorylation (3). These substrates include the ribosomal protein S6 kinase (RP S6K) and the eukaryotic initiation factor 4E binding protein 4EBP1, proteins necessary for cell growth and proliferation and responsive to nutrient and mitogen levels (4). Raptor binds these proteins through a common 5 amino acid TOR-signaling (TOS) motif; mutation of this motif prevents the TOR-dependent phosphorylation of these proteins (5).
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Raptor in L1210 cell lysate with Raptor antibody at (A) 2 and (B) 4 ug/ml.
IHC Image
Immunohistochemistry of Raptor in L1210 cells with Raptor antibody at 10 ug/ml.

 

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