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Anti-RPS6KB1 Antibody E175
Also for RPS6KB1 (NM_003161)
|A synthetic phospho-peptide corresponding to residues surrounding Thr389 of human p70 S6 kinase was used as immunogen. The antibody only detects p70 S6 kinase phosphorylated on Threonine 389. Predicted to cross-react with mouse, rat and bovine, based on s|
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1: 1,000-1:5,000; IHC: 1:50; IP: 1:60
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 (RPS6KB1), transcript variant 1|
|p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; PS6K; S6K; S6K-beta-1; S6K1; STK14A|
|p70 S6 Kinase is a mitogen-activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1). p70 S6 kinase phosphorylates specifically ribosomal protein S6. Activation of p70 S6 kinase is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains (2). Activation occurs via phosphorylation at Ser411, Thr421 and Ser424 within the pseudosubstrate region (3, 4). Phosphorylation of Thr229 in the catalytic domain and Thr389 in the linker domain are most critical for kinase function (2).|
TGF Beta Signaling Pathway
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- Anti-S6K antibody [E175]; Anti-S6K1 antibody [E175] + 293T cell lysate.Predicted band size : 59 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-S6K antibody [E175]; Paraffin-embedded human breast carcinoma.TA300314 at 1/50 dilution