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Anti-RPS6KA6 Antibody EP1524Y
Also for RPS6KA6 (NM_014496)
|A synthetic peptide corresponding to residues surrounding serine 235 of human Rsk 4 was used as an immunogen.|
||Tissue culture supernatant
||0.5~1.0 mg/ml (Lot Dependent)
||WB: 1:5000 - 1:10000; IHC-P: 1:50 - 1:100; ICC/IF: 1:100 - 1:250
|Does not react with Rat. Is unsuitable for Flow Cyt or IP.|
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
|Is unsuitable for Flow Cyt or IP.
|Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 6 (RPS6KA6)|
|RSK4 is a member of the family of 90-kDa ribosomal S6 kinases (1). These proteins are a class of serine/threonine kinases that are activated in response to various extracellular signals, including growth factors, polypeptide hormones and neurotransmitters (2). RSK4 is most abundantly expressed in brain and kidney. The predicted protein of 746 amino acids shows a high level of homology to three previously isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RSK4 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RSK4 plays a role in normal neuronal development (3). |
MAPK signaling pathway
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Western blot - RSK4 (phospho S235) antibody [EP1524Y]; All lanes : Anti-RSK4 (phospho S235) antibody [EP1524Y] at 1/10000 dilution.Lane 1 : Hela cell lysate untreated.Lane 2 : Hela cell lysate treated with Calyculin A.Lysates/proteins at 10 µg per lane.Secondary.HRP labelled anti-rabbit at 1/2000 dilution.Predicted band size : 84 kDa.Observed band size : 84 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RSK4 (phospho S235) antibody [EP1524Y]; TA301027, at 1/50, staining human muscle tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)