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Anti-RPS6KA1 Antibody E238
Also for RPS6KA1 (NM_002953)
|A synthetic phospho-peptide corresponding to residues surrounding Thr359 and Ser363 of human RSK1 was used as immunogen. The antibody only detects RSK1 phosphorylated on Threonine 359 and Serine 363.|
||Lot dependent; please refer to CoA along with shipment
||WB: 1:1000 - 1:10000; IHC-P: Use at an assay dependent dilution; ICC: 1:50; IP: 1:40
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Is unsuitable for Flow Cyt.
|Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1|
|HU-1; MAPKAPK1A; RSK; RSK1|
|Rsk-1 (p90-Rsk-1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes Rsk-1, Rsk-2 and Rsk-3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-Rsk-1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).|
EGFR1 Signaling Pathway
MAPK signaling pathway
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Western blot - RSK1 p90 (phospho T359 + S363) antibody [E238]; All lanes : Anti-RSK1 p90 (phospho T359 + S363) antibody [E238] at 1/20000 dilution.Lane 1 : A431 cell lysate untreated.Lane 2 : A431 cell lysate treated with EGF.Predicted band size : 90 kDa.Observed band size : 90 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RSK1 p90 (phospho T359 + S363) antibody [E238]; Ab32413, at a 1/100 dilution, staining RSK1 p90 in paraffin embedded human cervical carcinoma tissue by Immunohistochemistry. .Left image : Untreated. .Right image : Treated with Phosphatase.