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Anti-RPS6KA1 Antibody E238


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SKU Description Amount Price Availability*  
  • Rabbit Monoclonal Antibody against RPS6KA1 (Clone E238)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401035) , 20ug Explanation
100ul $379 3-7 Days
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Also for RPS6KA1 (NM_002953)
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OriGene Data

ImmunogenA synthetic phospho-peptide corresponding to residues surrounding Thr359 and Ser363 of human RSK1 was used as immunogen. The antibody only detects RSK1 phosphorylated on Threonine 359 and Serine 363.
Clone NameE238 IsotypeIgG
Species ReactivityMouse, Rat, Human ConcentrationLot dependent; please refer to CoA along with shipment
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000 - 1:10000; IHC-P: Use at an assay dependent dilution; ICC: 1:50; IP: 1:40
Predicted MW Explanation 90 kDa
BufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
Note Is unsuitable for Flow Cyt.

Reference Data

Target NameHomo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 1 (RPS6KA1), transcript variant 1
Alternative NameHU-1; MAPKAPK1A; p90Rsk; RSK; RSK1
Database LinkNP_002944
Entrez Gene 6195 Human
Entrez Gene 20111 Mouse
Entrez Gene 81771 Rat
FunctionRsk-1 (p90-Rsk-1) is a member of a family of 90 kDa ribosomal protein S6 kinases, which includes Rsk-1, Rsk-2 and Rsk-3. These are broadly expressed serine/threonine protein kinases (1) activated in response to mitogenic stimuli, including extracellular signal-regulated protein kinases Erk1 and Erk2 (2). p90-Rsk-1 is activated by MAPK in vitro and in vivo via phosphorylation (3). Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB (2,4).
Related PathwayProtein KinaseDruggable Genome MAPK signaling pathwayOocyte meiosismTOR signaling pathwayLong-term potentiationNeurotrophin signaling pathwayProgesterone-mediated oocyte maturationMore Pathways >>

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Western blot - RSK1 p90 (phospho T359 + S363) antibody [E238]; All lanes : Anti-RSK1 p90 (phospho T359 + S363) antibody [E238] at 1/20000 dilution.Lane 1 : A431 cell lysate untreated.Lane 2 : A431 cell lysate treated with EGF.Predicted band size : 90 kDa.Observed band size : 90 kDa.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - RSK1 p90 (phospho T359 + S363) antibody [E238]; Ab32413, at a 1/100 dilution, staining RSK1 p90 in paraffin embedded human cervical carcinoma tissue by Immunohistochemistry. .Left image : Untreated. .Right image : Treated with Phosphatase.


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