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Home Antibody All anti-ROCK1 antibodies

Anti-ROCK1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA308951
  • Rabbit polyclonal antibody to ROCK1 (Rho-associated, coiled-coil containing protein kinase 1)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC417325) , 20ug
100ul 325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenRecombinant protein fragment contain a sequence corresponding to a region within amino acids 107 and 381 of ROCK1
Clone Name IsotypeIgG
Species ReactivityHuman Concentration0.68mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB:1:500-1:3000; IHC:1:500; IF:1:100-1:200;
Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Purification Purified by antigen-affinity chromatography.

Reference Data

Target NameHomo sapiens Rho-associated, coiled-coil containing protein kinase 1 (ROCK1)
Alternative NameP160ROCK; ROCK-I
Database LinkNP_005397
FunctionThis gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq]
Related Pathway
Focal Adhesion
Signaling by GPCR
TGF Beta Signaling Pathway
Wnt Signaling Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
A: A431 B: H1299 C: Molt-4 (anti-ROCK1 antibody diluted at 1:1000)
IHC Image
Immunohistochemical analysis of paraffin-embedded DLD1 xenograft , using ROCK1(anti-ROCK1 antibody) antibody at 1:500 dilution.
IF Image
Immunofluorescence analysis of methanol-fixed HeLa, using ROCK1(anti-ROCK1 antibody) antibody at 1:200 dilution.

 

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