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Home Antibody All anti-RHEB antibodies

Anti-RHEB Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA306216
  • Rabbit Polyclonal Rheb Antibody
  • FREE positive control: HEK293T cell transient overexpression lysate (LC417187) , 20ug
100ug 325 In Stock
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WB(1)
IHC(1)
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Also for RHEB (NM_005614)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRheb antibody was raised against a 15 amino acid peptide from the middle region of human Rheb.
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1 ug/ml
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens Ras homolog enriched in brain (RHEB)
Alternative NameRHEB2
Database LinkNP_005605
FunctionRheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure (1). While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway (2). Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway (3-5). TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2 (3).
Related Pathway

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WB Image
Western blot analysis of Rheb in mouse brain cell lysate with Rheb antibody at (A) 1, (B) 2, and (C) 4 ug/ml.
IHC Image
Immunohistochemistry of Rheb in mouse brain tissue with Rheb antibody at 2 ug/ml.

 

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