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Home Antibody All anti-RHBDD3 antibodies

Anti-RHBDD3 Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA306892 Rabbit Polyclonal RHBDD3 Antibody 100ug $325 3-7 Days
LC415869 RHBDD3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenRHBDD3 antibody was raised against a 13 amino acid peptide from near the center of human RHBDD3 .
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/mL, IF: 20 ug/mL
BufferPBS containing 0.02% sodium azide.
Purification Affinity chromatography purified via peptide column

Reference Data

Target NameHomo sapiens rhomboid domain containing 3 (RHBDD3)
Alternative NameC22orf3; HS984G1A; PTAG
Database LinkNP_036397
Entrez Gene 25807 Human
Entrez Gene 279766 Mouse
Entrez Gene 289753 Rat
FunctionThe Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD3 was initially identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression was reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells showed an increase in apoptotic activity and caspase activation in response to bromocriptine, and apoptosis-inducing dopamine D2 analog, suggesting that reactivation of RHBDD3 in tumors may be a therapeutically useful tool. Later experiments also showed that RHBDD3 expression is also reduced in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to a blunted apoptotic response and probably predisposes cells towards malignant transformation.
Related PathwayTransmembraneDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of RHBDD3 in rat lung tissue lysate with RHBDD3 antibody at 1 µg/ml.

IF Image
Immunofluorescence of RHBDD32 in rat lung tissue with RHBDD3 antibody at 20 ug/mL.


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