Home Antibody All anti-RGS21 antibodies
Also for RGS21 (NM_001039152)
|RGS21 antibody was raised against a 16 amino acid peptide near the center of human RGS21.|
||WB: 0.5 ug/ml, ICC: 2.5 ug/ml, IF: 20 ug/ml
|PBS containing 0.02% sodium azide.|
|Affinity chromatography purified via peptide column
|Homo sapiens regulator of G-protein signaling 21 (RGS21)|
Entrez Gene 431704 Human
|Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.|
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Western blot analysis of RGS21 in HepG2 cell lysate with RGS21 antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunocytochemistry of RGS21 in HepG2 cells with RGS21 antibody at 2.5 ug/mL.