Home Antibody All anti-REN antibodies
|Recombinant protein fragment contain a sequence corresponding to a region within amino acids 70 and 302 of Human REN|
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Homo sapiens renin (REN)|
Entrez Gene 5972 Human
|Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq]|
|Secreted ProteinDruggable Genome Renin-angiotensin system|
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Sample(30 ug whole cell lysate) A:293T (anti-REN antibody diluted at 1:1000)
Immunohistochemical analysis of paraffin-embedded OVCA xenograft, using Renin(anti-REN antibody) antibody at 1:100 dilution.