Home Antibody All anti-REN antibodies
|Recombinant fragment corresponding to a region within amino acids 70 and 332 of Renin (Uniprot ID#P00797)|
|Human (Predicted: Chimpanzee)
|0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.|
|Purified by antigen-affinity chromatography.
|Seq homology of immunogen across species: Chimpanzee (100%)
|Homo sapiens renin (REN)|
Entrez Gene 5972 Human
|Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq]|
|Secreted ProteinDruggable Genome Renin-angiotensin system|
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Renin antibody [N2C2], Internal detects REN protein by Western blot analysis. A. 30 ug K562 whole cell lysate/extract. 10 % SDS-PAGE. Renin antibody [N2C2], Internal (TA308950) dilution: 1:1000
Immunohistochemical analysis of paraffin-embedded OVCA xenograft, using Renin(TA308950) antibody at 1:100 dilution.