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Home Antibody All anti-RELA antibodies

Anti-RELA PHOSPHO Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA325807
  • Rabbit Polyclonal NF-?B p65 (Ser536) Antibody (Phospho-specific)
100ul 325 3 Weeks
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WB(1)
IHC(1)

OriGene Data

ImmunogenA synthesized peptide derived from human NF-?B p65 around the phosphorylation site of Sersine 536
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500-1:2000; IHC: 1:50-1:200
BufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.

Reference Data

Target NameHomo sapiens v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA), transcript variant 2
Alternative NameNFKB3; p65
Database LinkNP_001138610
Entrez Gene 5970 Human
Entrez Gene 19697 Mouse
Entrez Gene 309165 Rat
FunctionProteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF?B (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind to DNA sequences that are the same or slight variations of the 10 bp kB sequence in the immunoglobulin ? light chain enhancer. This same sequence is also present in a number of other cellular and viral enhancers. The DNA binding activity of NF?B is activated and rapidly transported from the cytoplasm to the nucleus in cells exposed to mitogens or growth factors. cDNAs encoding precursors for two distinct 50 kDa proteins have been described, designated p105 and p100, respectively. The p105 precursor contains p50 at its amino terminus and a C-terminal region that when expressed as a separate molecule, designated PDI, binds to p50 and regulates its activity.
Related PathwayTranscription FactorsDruggable Genome MAPK signaling pathwayChemokine signaling pathwayApoptosisToll-like receptor signaling pathwayNOD-like receptor signaling pathwayRIG-I-like receptor signaling pathwayMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of extracts from K562 cells , using Phospho-NF-kappaB p65 (Ser536) Antibody. The lane on the right is treated with the synthesized peptide.
IHC Image
Immunohistochemistry analysis of paraffin- embedded human breast carcinoma, using NF-kappaB p65 (Phospho-Ser536) Antibody.?

 

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