Novel HIF2A mutations disrupt oxygen sensing, leading to polycythemia, paragangliomas, and somatostatinomas Blood, Mar 2013; 121: 2563 - 2566.
[anti-HA]
Regulation of the PI3-K/Akt Survival Pathway in the Rat Endometrium Biol Reprod, Mar 2013; 88: 79.
[Akt3]
RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP Nucleic Acids Res., Mar 2013; 10.1093/nar/gkt159.
[LA]
Ruxolitinib as potential targeted therapy for patients with JAK2 rearrangements Haematologica, Mar 2013; 98: 404 - 408.
[JAK2]
RCC1, or Regulator of chromosome condensation 1, is the guanine nucleotide exchange factor for Ran GTPase. Localized generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly, and nuclear envelope formation. Both the N-terminal tail of RCC1 and its association with Ran are important for its interaction with chromatin in cells, demonstrated by RCC1’s ability to bind histones H2A and/or H2B in a Ran-regulated manner (1, 2). RCC1 also binds both to the nucleosomes and double-stranded DNA. The RCC1-Ran complex, together with other proteins, acts as a component of a signal transmission pathway that detects unreplicated DNA (3).
Related Pathway
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