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Home Antibody All anti-RASA1 antibodies

Anti-RASA1 TRUEMAB Antibody Clone 4E2

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA505935
  • RASA1 (GAP ) mouse monoclonal antibody, Clone 4E2
  • FREE positive control: HEK293T cell transient overexpression lysate (LC401014) , 20ug
100ul $325 In Stock
CF505935
  • Carrier-free (BSA/glycerol-free) RASA1 mouse monoclonal antibody,clone 4E2
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IF(1)
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Also for RASA1 (NM_002890)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human RASA1(NP_002881) produced in HKE293T cell.
Clone NameClone 4E2 IsotypeIgG1
Species ReactivityHuman Concentration1mg/ml
Guaranteed Application *WB, IF Suggested Dilutions WB 1:2000, IF 1:100,
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens RAS p21 protein activator (GTPase activating protein) 1 (RASA1), transcript variant 1
Alternative NameCM-AVM; CMAVM; GAP; p120GAP; p120RASGAP; PKWS; RASA; RASGAP
Database LinkNP_002881
FunctionThe protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].
Related Pathway
EGFR1 Signaling Pathway
MAPK signaling pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RASA1 (RC205473, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RASA1.
IF Image
Anti-RASA1 mouse monoclonal antibody (TA505935) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RASA1(RC205473).

 

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