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Anti-RAP1A Antibody EP879Y
Also for RAP1A (NM_002884)
|A synthetic peptide corresponding to residues near the N-terminus of human Rap 1 was used as an immunogen.|
|Mouse, Rat, Human
||Lot dependent; please refer to CoA along with shipment
||WB: 1:500; IP: 1:40; ICC: 1:100 - 1:250
|PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%|
|Tissue culture supernatant
|Is unsuitable for Flow Cyt or IHC-P.
|Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2|
|C21KG; G-22K; KREV-1; KREV1; RAP1; SMGP21|
Entrez Gene 5906 Human
Entrez Gene 109905 Mouse
Entrez Gene 295347 Rat
|Rap1, also known as Krev-1 and smg p21, is a member of the Ras super family of GTPases closely related to Ras. Two known isoforms of Rap1 exists, Rap1A and Rap1B which share 95% identity (1-2). As a molecular switch, Rap1 cycles between two conformational states depending on whether GDP bound (active form) or GTP bound (inactive form). Rap1 associates with a subset of Ras effectors including Raf-1, B-Raf, phosphoinositide 3-kinase, Ral GEFs, and PLC (3). Although its function is still unclear, Rap1 has been shown to be involved in the regulation of integrin-mediated cell adhesion (4). |
|Druggable Genome MAPK signaling pathwayChemokine signaling pathwayFocal adhesionLeukocyte transendothelial migrationLong-term potentiationNeurotrophin signaling pathwayMore Pathways >> |
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Western blot - RAP1 antibody [EP879Y]; Anti-RAP1A + RAP1B antibody [EP879Y] at 1/500 dilution + human brain lysate at 10 ug.Secondary.Goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 21 kDa.Observed band size : 21 kDa.